I didn't put any ketchup in the meatloaf i used a different sauce for over the top which consists of:

2Tbs brown sugar
2Tbs regular mustard (like "smile you've got frenches" kind)
1/3c ketchup
mix it all together then spread over top of meat loaf then cook.

I substituted the ketchup for tomato sauce, ketchup makes it sweeter, tomato sauce is more tangy (personal preference).

Try using v8 instead of ketchup - comes out just as good.

I use salsa! It's delicious!!

In my family's opinion, use Manwich original sauce, 1 can, in place of ketchup for in the mixture. Then top with ketchup at the last. It is so much more delectably delicious!

The bold Manwich sauce is great also :)

We use a can of spaghetti sauce in place of ketchup and we sometimes also add a packet of chili or taco spices. Cooked in the oven at 400°F for 30 minutes, it's really quite good. You can also substitute a pepper (red, green, etc.) for one of the small onions. (Stuff small chunks of meatloaf into taco shells and serve with lettuce and grated cheese, too, if you like).